LUF (Flucloxacillin) is used primarily for the treatment of infections due to staphylococci resistant to
• Skin and soft tissue infections : boil, carbuncles, abscesses, infected skin conditions (ulcer, eczema, and acne) furunculosis, cellulitis, infected wounds, infected burns, otitis media, external impetigo and protection for skin grafts
•Respiratory tract infections : pneumonia, lung abscess, emphema, sinusitis, pharyngitis, tonsillitis, quinsy
•Bone and joint infections : osteomyelitis
•Other infections caused by Flucloxacillin sensitive organism : enteritis, endocarditis, urinary tract
infections, meningitis, septicaemia
•As a prophylactic agents during major surgical procedures where appropriate Cardiothoracic &
Dosage and administration:
Dose should be individualized, depending on patient's conditions and response.
LUF (Flucloxacillin) should be administered at least 30 minutes before meal.
Adults: 250 mg - 500 mg (1 LUF-250 cap -1 LUF-500 cap) every 6 hours.
Children: Under 2 years: 62.5 mg -125 mg (2.5 ml -5 ml LUF PFS) every 6 hours.
2-10 years: 125 mg - 250 mg (5 ml -10 ml LUF PFS) every 6 hours.
In endocarditis: Body weight under 85 kg : Up to 8 gm daily in 3-4 divided doses. Body weight over 85
kg : up to 12 gm in 6 divided doses.
In osteomyelitis: Up to 8 gm daily in 3-4 divided doses.
In renal impairment: Dose or dose interval may need adjustment.
In hepatic impairment: Adjustment of dosage may not be necessary.