Product Details

Lequin ®
Levofloxacin
Antibiotic

Brief:
Levofloxacin

Indication:
LEQUIN (Levofloxacin) is indicated in the following infectionsl Community-acquired pneumonia due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneumoniae, Legionella pneumophila, or Mycoplasma pneumoniae • Nosocomial pneumonia due to methicillin-susceptible Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, or Streptococcus pneumoniae
• Acute maxillary sinusitis due to Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis
• Acute exacerbation of chronic bronchitis due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis
• Complicated & uncomplicated skin and soft tissue infections due to Staphylococcus aureus, Streptococcus pyogenes, Proteus mirabilis or Enterococcus faecalis
• Chronic bacterial prostatitis due to Escherichia coli, Enterococcus faecalis, or Staphylococcus epidermidis.
• Complicated & uncomplicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, or Staphylococcus saprophyticus
• Acute pyelonephritis caused by Escherichia coli
• Enteric fever caused by Salmonella typhi or Salmonella paratyphi
• Inhalational anthrax treatment and post-exposure prophylaxis.

Dosage and administration:
Infection Daily Dose Treatment Duration
Community-Acquired Pneumonia
500 mg 7-14 days
700 mg 5 days
Nosocomial Pneumonia 750 mg 7-14 days
Acute Bacterial Sinusitis 500 mg 10-14 days
750 mg 5 days
Acute Exacerbation of Chronic Bronchitis 500 mg 7days
Skin and Skin Structure
Infections
Uncomplicated 500 mg 7-10 days
Complicated 750 mg 7-14 days
Chronic bacterial prostatitis
500 mg 28 days
Urinary Tract Infections Uncomplicated 250 mg 3 days
Complicated 250 mg 10 days
Pyelonephritis 250 mg 10 days
Inhalational anthrax ( post-exposure) 500 mg 60 days
LEQUIN (Levofloxacin) can be administered without regard to food but should be administered at least 2 hours before the administration aluminum/magnesium-containing antacids, sucralfate, metal cations such as iron, and multivitamin preparations with zinc. Patients are advised to drink fluids liberally when received Levofloxacin to avoid crystalluria. In renal impairment : After initial doses, subsequent doses should be reduced according to Creatinine Clearance (CC) : CC 20-50 ml/ min : ½ of the initial dose, CC 10- 19 ml/ min : ¼ of the initial dose (a regimen of 250 mg daily should be reduced to 125 mg every other day), CC <10 ml/min : initial dose of 250 mg or 500 mg daily reduced to 125 mg every 48 or 24 hrs respectively.

Apex Pharma Limited
House # 06, Road # 137,
Block # SE (D), Gulshan, Dhaka-1212
Tel: 9863026, 8856717
Fax: 880-2-8856743
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