Product Details

Ranul ®
Ranitidine
Antiulcerant

Brief:
Ranitidine

Indication:
Ranul (Ranitidine) is indicated for the treatment or symptomatic relief of various gastric disorders and other conditions where reduction of gastric acid secretion and acid output is desirable, like • Benign gastric and duodenal ulcer • NSAID-induced ulcer • Prophylaxis of NSAID-induced ulcer • Duodenal ulcer associated with H. pylori in combination with antibiotics • Chronic episodic dyspepsia • Gastro-esophageal reflux disease (GERD) • Pathological acid hypersecretory conditions, such as Zollinger-Ellison Syndrome (ZES) • Gastric acid reduction (prophylaxis of acid aspiration) • Prophylaxis of stress ulcer

Dosage and administration:
Benign gastric ulcer and duodenal ulcer Treatment dose 150 mg twice daily or 300 mg single dose at bed time for 4 to 8 weeks. A dose of 300 mg twice daily for 4 weeks can be given in duodenal ulcer to achieve a higher healing rate
Maintenance dose 150 mg daily at bed time
NSAID-induced ulcer 150 mg twice daily or 300 mg single dose at bed time for 8 weeks
Prophylaxis of NSAID-induced ulcer 150 mg-300 mg twice daily
Duodenal ulcer associated with H. pylori 300 mg Ranitidine once daily or 150 mg twice daily + 750 mg Amoxicillin 3 times a day + 500 mg Metronidazole 3 times a day for 2 weeks. Therapy with Ranitidine should then be continued for a further 2 weeks
Chronic episodic dyspepsia 150 mg twice daily or 300 mg single dose at bed time for 6 weeks
Gastroesophageal reflux disease (GERD) Normal 150 mg twice daily or 300 mg single dose at bed time for 8 weeks or if necessary 12 weeks
Moderate to severe 600 mg daily in 2-4 divided doses for up to 12 weeks
Maintenance dose 150 mg twice daily
Pathological acid hypersecretory conditions, such as Zollinger-Ellison Syndrome (ZES) 150 mg 3 times daily; dose up to 6 g daily in divided doses have been used
Gastric acid reduction (prophylaxis of acid aspiration) In obstetrics 150 mg at onset of labour, then every 6 hours
Surgical procedures 150 mg 2 hours before induction of anaesthesia and preferably also 150 mg the previous evening
Prophylaxis of stress ulcer After IV Ranitidine administration, doses of 150 mg twice daily may be given when oral feeding commences
In renal impairment : In renal impairment the mean elimination half-life of Ranitidine is increased to double and therefore dosage of Ranitidine should be reduced in patients with severe renal impairment and suggested doses is 150 mg daily. Children : The recommended oral dose for the treatment of duodenal and gastric ulcer in children is 2 to 4 mg/kg twice daily to a maximum of 300 mg/day.

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