Product Details

Preform ®
Metformin HCl
Antidiabetic

Brief:
Metformin Hydrochloride

Indication:
As monotherapy: PREFORM (Metformin Hydrochloride) is indicated to lower blood glucose in patients with non-insulin-dependent diabetes mellitus (Type-2) whose hyperglycemia cannot be satisfactory managed on diet & exercise alone. In combination:PREFORM (Metformin Hydrochloride) may be used concomitantly with sulfonylurea,repaglinide, pioglitazone, acarbose or insulin when diet and monotherapy does not result in adequate gylcemic control. As an adjuvant: In insulin dependent diabetes mellitus (Type-1) PREFORM (Metformin Hydrochloride)may be given as an adjuvant to obese patients.

Dosage and administration:
Dosage must be individualized on the basis of both effectiveness and tolerance. A lower recommended starting dose and gradually increased dose is advised to minimize GI symptoms. Dose of PREFORM tablet two or three times daily or 850 mg once or twice daily with or after meals.Dosage can be increased gradually if necessary to 2000 to 3000 mg daily. Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks given in divided doses. Doses above 2000 mg daily are associated with an increased incidence of GI adverse effects. Dose of PREFORM-SR tablet : PREFORM-SR tablet is a sustained release formulation of Metformin, designed for once daily and better GI tolerance. The usual starting dose is once daily with the evening meal.Dosage increases should be made increments of 500 mg weekly, upto a maximum of 2000 mg once daily. Transfer from other antidiabetic therapy to PREFORM (Metformin) therapy: When transferring patients from oral hypoglycemic agents other than chlorpropamide to PREFORM (Metformin Hydrochloride), no transition period generally is necessary. When transferring patients from chlorpropamide, care should be exercised during the first two weeks because of the prolonged retention of chlorpropamide in the body,leading to overlapping drug effects and possible hypoglycemia. Transfer from Metformin (PREFORM) to sustained release Metformin (PREFORM-SR): Patients currently treated with Metformin can be safely switched to sustained release Metformin (PREFORM-SR) once daily at the same total daily dose, up to 2000 mg once daily.

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