Cepoxid

Generic Name: Cefpodoxime

Therapeutic Class: Antibiotic

View Prescribing Detail

Composition
Cepoxid 200 Tablet : Each tablet contains Cefpodoxime Proxetil USP equivalent to 200 mg Cefpodoxime.
Cepoxid PFS : When reconstituted each 5 ml suspension contain Cefpodoxime Proxetil USP equivalent to 40 mg
Cefpodoxime.
Pharmacology
Cepoxid (Cefpodoxime Proxetil) is an orally administered extended spectrum, semi-synthetic 3 rd generation antibiotic of
cephalosporin group. Cefpodoxime Proxetil is a bactericidal drug that acts by inhibition of bacterial cell wall synthesis.
Cefpodoxime Proxetil is highly stable in the presence of beta-lactamases produced by most gram-negative pathogens and
active against organisms that are resistant to other beta-lactam antibiotics because of beta-lactamase production.
Cefpodoxime Proxetil is a prodrug, is absorbed from the GIT and de-esterified to its active metabolite, Cefpodoxime.
Indication
Cepoxid (Cefpodoxime) is indicated in the following infections: (1) Lower Respiratory Tract Infections (LRTI): Acute community acquired pneumonia (CAP), Acute bacterial exacerbation of chronic bronchitis. (2) Upper Respiratory Tract Infections (URTI): Acute otitis media, Acute maxillary sinusitis, Pharyngitis, Tonsillitis. (3) Sexually Transmitted Diseases (STD): Acute uncomplicated urethral & cervicaI gonorrhea, Acute ano-rectal infection in woman caused by N. gonorrhea. (4)Uncomplicated Urinary Tract Infections (UUTI): Cystitis, Pyuria. (5) Skin & Soft Tissue Infections (SSTI): Furuncle, Cellulitis, Subcutaneous abscess, infectious atheroma & periproctal abscess. (6) Enteric Fever: Typhoid, Para-typhoid.
Dosage & Administration
Cepoxid Suspension may be given without regard to food. The recommended doses, duration of treatment, applicable
patient population are as below:
Adults (including age 12 years & older) :
Children:
15 days - 6 months : 4 mg/kg every 12 hours
6 months - 2 years : 40 mg every 12 hours
3 years - 8 years : 80 mg every 12 hours
Over 9 years : 100 mg every 12 hours
Patients with renal dysfunction : For patients with severe renal impairment (creatinine clearance < 30 ml/min) the dosing
intervals should be increased to 24 hourly.
Patients with liver cirrhosis : Cefpodoxime Proxetil pharmacokinetics in cirrhotic patients are similar to those in healthy
subjects. Dose adjustment is not necessary in this population.
Contraindication
Cepoxid is contraindicated in known hypersensitivity to Cefpodoxime or to the Cephalosporin group of antibiotics and in
porphyria.
Precaution
In renal insufficiency, the total daily dose of Cefpodoxime proxetil should be reduced. Cefpodoxime, like other
cephaIosporins, should be administered with caution to patients receiving concurrent treatment with potent diuretics.
Side Effect
Cefpodoxime has very few side effects. The side effects include diarrhea, nausea, abdominal pain, headache, chest pain,
myalgia, dyspepsia. dizziness, vertigo, cough etc.
Use in Pregnancy & Lactation
Pregnancy: The drug should be used during pregnancy only if clearly needed. Pregnancy Category B.
Lactation: Cefpodoxime is excreted in human milk. So patient taking this drug should not breast-feed.
Drug Interaction
Antacids: Concomitant administration of antacids or H 2 blockers reduces absorption of Cefpodoxime. Probenecid: Inhibited
renal excretion of Cefpodoxime.
Direction For Reconstitution of Suspension
First shake the bottle until all powder flows freely. Then add boiled & cool water 25 ml (5 teaspoonfull) in the bottle and
shake vigorously to suspend powder. For better mixing add total water in two portion and shake vigorously each time.
Note: After reconstitution keep the bottle tightly closed and shake the bottle well before each use. Reconstituted suspension
must be used within 7 days if kept at room temperature or within 10 days when stored in a refrigerator.
Overdose
Overdosage may cause toxic reaction. Toxic symptoms include nausea, vomiting, epigastric distress, diarrhea.