Delot

Composition
DELOT Tablet: Each film-coated tablet contains Desloratadine BP 5mg.
DELOT Syrup: Each 5ml syrup contains Desloratadine BP 2.5mg.
Pharmacology
DELOT is a preparation of Desloratadine. Desloratadine is apotent, rapidly effective, long-acting, non-sedative
antihistamine with selective H1-receptor histamine antagonist activity. It is a non-sedating antihistamine. Desloratadine
has effects on the chronic inflammatory response to allergens and no effect on the QT interval of ECG.
Indication
Allergic Rhinitis: DELOT is indicated for the relief of the nasal and non-nasal symptoms of allergic rhinitis (Both
seasonal and perennial) in patients 2 years of age and older.
Chronic Idiopathic Urticaria: DELOT is also indicated for the symptomatic relief of pruritus, reduction in the number
of hives, and size of hives, in patients with chronic idiopathic urticaria 2 years of age and older.
Dosage and Administration
Adult & over 11 years: Tablet: One tablet (5 mg) once daily or
Syrup: 10 ml (2 teaspoonful) once daily.
Child 6-11 years: Syrup: 5 ml (1 teaspoonful) once daily or
Tablet: 2.5 mg (half of one 5 mg tablet) once daily.
Child 2-5 years: Syrup: 2.5 ml (1/2 teaspoonful) daily or as directed by the physician.
In patients with liver or renal impairment: Starting dose of one tablet every alternate day.
Contraindication
DELOT is contraindicated in patients who are hypersensitive to this medication or to any of its ingredients or to
Loratadine.
Precaution
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose
malabsorption should not take this medicine. In general, dose selection for an elderly patient should be cautious,
reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other
drug therapy.
Side Effect
In general DELOT is well tolerated. Clinical trials suggest a very low rate of adverse effects commonly reported by small
percentage of patients are dry mouth, fatigue, myalgia and somnolence. Less common side effects may include
headache, nausea, dizziness, dyspepsia, pharyngitis etc.
Use in Pregnancy & Lactation
Pregnancy: Pregnancy Category C. There are no adequate and well-controlled studies of desloratadine in pregnant
women. Desloratadine should be used during pregnancy only if the potential benefit justifies the risk to the fetus.
Nursing Mothers: Desloratadine passes into human breast milk; therefore, a decision should be made whether to
discontinue desloratadine, taking into account the importance of the drug to the mother.
Drug Interaction
Concomitant administration of Erythromycin, Ketoconazole, Azithromycin, Fluoxetine and Cimetidine with
Desloratadine increased the plasma concentration of Desloratadine. But there were no clinically relevant changes in the
safety profile of Desloratadine.

Store between 2° and 25° C. Heat sensitive. Avoid exposure at or above 30° C.