Fixgut

Generic Name: Domperidone

Therapeutic Class: Gastroprokinetics

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Composition
Fixgut Tablet: Each film coated tablet contains Domperidone maleate BP equivalent to 10 mg Domperidone.
Fixgut Suspension: Each 5 ml suspension contains Domperidone BP 5 mg.
Pharmacology
Domperidone is a selective peripheral dopamine D2 receptor antagonist. Principally it acts in the chemoreceptor trigger zone (CTZ) and stomach.
Indications
Prevention & symptomatic relief of acute nausea and vomiting of adults (from any cause specially due to cytotoxic therapy & radiotherapy). Nausea & vomiting associated with L-dopa and bromocriptine treatment for parkinsonian patients. Nausea & vomiting due to migraine, head injury, pancreatitis, gastritis, hepatitis, post-gastrectomy syndrome, haemodialysis and dysmenorrhoea. Non ulcer dyspepsia, oesophageal reflux,
reflux oesophagitis & gastritis. Speeding of barium transit in 'follow through' radiological studies.
Dosage & Administration
Adult & Elderly patients: 10-20 mg every 4-8 hours. Domperidone should be taken 15-30 minutes before meal or
as directed by the physician.
Contraindications
Domperidone is contraindicated in patients with known allergy or hypersensitivity, prolactinoma and in
pregnancy. It should be used cautiously in children unless indicated for the management of nausea and
vomiting following cancer chemotherapy or irradiation therapy.
Precautions
The drug is not recommended for use in neonates. Domperidone may precipitate galactorrhoea & improve
post-natal lactation.
Side Effects
Domperidone increases level of serum prolactin which may be associated with galactorrhoea & gynaecomastia. Occasionally, rash and other allergic phenomena have been reported. Besides dry mouth, thirst, headache, diarrhoea, skin rash and reduced libido may follow treatment with domperidone.
Use in Pregnancy & Lactation
Domperidone should not be used in pregnant women unless the expected benefit outweighs any potential risk. Domperidone is excreted in breast milk in very low concentration. Hence, it is not recommended in lactating mothers.
Use in Children & Adolescents
The safety and efficacy of Domperidone in children have not been established. So, Domperidone should not be used in children.
Drug Interactions
Domperidone may reduce the hypoprolactinaemic effect of bromocriptine. Antacids and anti-secretory agents lower the oral bioavailability of domperidone, so they should be taken after meals and not with domperidone
simultaneously.
Overdosage
Overdose has been reported primarily in infants and children. Symptoms of overdose may include agitation, altered consciousness, convulsion, disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone. Anticholinergic agents may be helpful in controlling the extrapyramidal reactions. Close observation and supportive therapy is recommended.