Naproxen is indicated for the relief of symptoms of rheumatoid arthritis, both of acute flares and for long term management of the disease. It is also used in the diseases of rheumatoid osteoarthritis (degenerative arthritis), ankylosing spondylitis, juvenile rheumatoid arthritis, tendinitis, bursitis, acute gout, acute musculoskeletal disorders (such as sprains, direct trauma and fibrositis), migraine and dysmenorrhoea.

Rheumatic disease: 0.5–1 g daily in 1–2 divided doses; child (over 5 years), juvenile idiopathic arthritis: 10 mg/kg daily in 2 divided doses. Acute musculoskeletal disorders and dysmenorrhoea: 500 mg initially, then 250 mg every 6–8 hours as required; max. dose after first day 1.25 g daily; child under 16 years not recommended. Acute gout: 750 mg initially, then 250 mg every 8 hours until attack has passed; child under 16 years not recommended.