Indication:
Baclofen is indicated for... Muscle spasm Tension type headache The alleviation of spasticity resulting from multiple sclerosis Spinal cord diseases Muscle spasm of cerebral origin especially infantile cerebral palsy Cerebrovascular accidents or neoplastic or degenerative brain disease.
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Dosage and administration:
Adults: For the management of spasticity, the initial oral dosage of Baclofen is 5 mg 3 times daily. Oral daily dosage may be increased by 15 mg at 3 day intervals, until optimum effect is achieved (usually at dosages of 40-80 mg daily). In patients with psychiatric or brain disorders and in geriatirc patients, oral dosage should be increased more gradually. In some patients, a smoother antispastic effect is obtained by administering the oral daily dosage in 4 divided doses. Children: Treatment should be started at a very low dose e.g. 0.3 mg/kg body weight per day in divided doses. The dosage should be raised cautiously at 1-2 week intervals until it is sufficient for the child's individual needs. The usual dosage range for maintenance therapy is 0.75 to 2 mg/kg body weight per day. In children aged over 10 years a maximum daily dose of 2.5 mg/kg body weight may be given.