Product Details

Nexe ®


NEXE (Esomeprazole) is indicated for the treatment or symptomatic relief of various gastric disorders including • Gastric and duodenal ulcers • NSAID-induced duodenal or gastric ulcers and gastroduodenal erosions • Prophylaxis of NSAID-induced gastroduodenal complications in patients who require continued NSAID treatment • Gastroduodenal ulcer associated with Helicobacter pylori in combination with antibiotics • Gastro-oesophageal reflux disease (GERD)/Reflux oesophagitis, erosive oesophagitis • Acid-related dyspepsia • Zollinger-Ellision Syndrome. longines replica watches

Dosage and administration:
Dosage should be individualized, depending on patient's condition and response. NEXE(Esomeprazole) should be taken before meal.
Benign gastric ulcer and duodenal ulcer Treatment dose 150 mg twice daily or 300 mg single dose at bed time for 4 to 8 weeks. A dose of 300 mg twice daily for 4 weeks can be given in duodenal ulcer to achieve a higher healing rate
Maintenance dose 150 mg daily at bed time
NSAID-induced ulcer 150 mg twice daily or 300 mg single dose at bed time for 8 weeks
Prophylaxis of NSAID-induced ulcer 150 mg-300 mg twice daily
Duodenal ulcer associated with H. pylori 300 mg Ranitidine once daily or 150 mg twice daily + 750 mg Amoxicillin 3 times a day + 500 mg Metronidazole 3 times a day for 2 weeks. Therapy with Ranitidine should then be continued for a further 2 weeks
Chronic episodic dyspepsia 150 mg twice daily or 300 mg single dose at bed time for 6 weeks
Gastroesophageal reflux disease (GERD) Normal 150 mg twice daily or 300 mg single dose at bed time for 8 weeks or if necessary 12 weeks
Moderate to severe 600 mg daily in 2-4 divided doses for up to 12 weeks
Maintenance dose 150 mg twice daily
Pathological acid hypersecretory conditions, such as Zollinger-Ellison Syndrome (ZES) 150 mg 3 times daily; dose up to 6 g daily in divided doses have been used
Gastric acid reduction (prophylaxis of acid aspiration) In obstetrics 150 mg at onset of labour, then every 6 hours
Surgical procedures 150 mg 2 hours before induction of anaesthesia and preferably also 150 mg the previous evening
Prophylaxis of stress ulcer After IV Ranitidine administration, doses of 150 mg twice daily may be given when oral feeding commences
Gastric ulcers 20-40 mg once daily for 4-8 weeks
GERD Treatment dose 40 mg once daily for 4 weeks, continued for further 4 weeks if not fully healed or symptoms persist
Maintenance dose 20 mg daily
Symptomatic treatment in the absence of oesophagitis 20 mg daily for up to 4 weeks, then 20 mg daily when required
NSAID-induced ulcers 20 mg once daily for 4-8 weeks
Prophylaxis of NSAID-induced gastroduodenal complications 20 mg daily
Acid-related dyspepsia 20-40 mg once daily for 2-4 weeks according to response
Zollinger-Ellison syndrome 20-80 mg once daily, the dose should be adjusted individually and treatment continued as long as clinically indicated
Eradication of Helicobacter pylori 20 mg Esomeprazole twice daily + Amoxicillin 1000 mg twice daily / Metronidazole 400 mg twice daily + 500 mg Clarithromycin
Renal impairment:Dose adjustment is not required. Hepatic impairment:No dosage adjustment is necessary in mild to moderate hepatic impairment but in severe hepatic impairment the maximum daily dose of Esomeprazole is 20 mg

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