Prophylaxis of classic (with aura) or common (without aura) migraine. Symptomatic treatment of vestibular vertigo, dizziness. Peripheral vascular disease (Intermittent claudication, Raynaud's phenomenon, paresthesiae, cold extremities, nocturnal cramp and trophic disorders owing to ischaemia of limbs). Refractory epilepsy resistant to conventional antiepileptic therapy. Alternating hemiplegia of childhood.
Dosage and administration:
DOSAGE AND ADMINISTRATION The usual dose is 5 to 10 mg daily, usually given at night to minimize the effects of drowsiness. For migraine prophylaxis: Starting dose is 10 mg daily (at night) for patients less than 65 years and 5 mg daily for patients older than 65 years. For vertigo: The recommended maximum daily dose of flunarizine in the treatment of vertigo is 10 mg daily in adults and 5 mg daily in children ( < 40 kg). For epilepsy: An optimal therapeutic dosage in epileptic patients receiving other anti- epileptic drugs is 15 mg to 20 mg daily in adults and 5 to 10 mg daily in children. Maintenance treatment: If a patient's response is satisfactory and if a maintenance treatment is needed, the dose should be decreased so that each week the patient has 5 days treatment at the same daily dose and 2 successive drug free days. Treatment should be interrupted after 6 months and re-initiated only if the patient relapses. The recommended maximum daily dose is 10 mg daily in adults and 5 mg daily in children (< 40 kg).